Accumulation of p27(kip1) is associated with cyclin D3 overexpression in the oxyphilic (Hurthle cell) variant of follicular thyroid carcinoma
نویسندگان
چکیده
منابع مشابه
تشخیص یک مورد کارسینوم شبه وارتینی تیروئید حین عمل توسط سیتولوژی
Warthin-like papillary carcinoma of the thyroid is a recently described variant of papillary thyroid carcinoma characterized histologically by a papillary structure and oxyphilic tumor cells in a chronic lymphocytic thyroiditis background. In this article, a tumoral mass of a 19-year-old female was studied cytologically and histologically. The patient complained of neck mass and was operated as...
متن کاملPropensity score matching analysis of the prognosis for the rare oxyphilic subtype of thyroid cancer (Hurthle cell carcinoma)
There is controversy regarding the prognosis of patients with oxyphilic thyroid cancer (OXTC). The present study compared the prognoses of OXTC, papillary thyroid cancer (PTC), and follicular thyroid cancer (FTC), in order to provide a new perspective regarding the treatment guidelines for these diseases. We evaluated data from patients with thyroid cancer who were included in the Surveillance,...
متن کاملRetrospective analysis of I-131 therapy in patients with follicular carcinoma of the thyroid [Persian]
In research institute for nuclear medicine (Tehran University of Medical Sciences) 50 patients with follicular thyroid carcinoma were evaluted retrospectively. The purpose of the study was assesment of the response of iodine-131 therapy. The best result were achieved when the patient treated with iodine-131 for the first time, in the 4th decade of life, with total thyroidectomy and no met...
متن کاملClear cell variant of follicular thyroid carcinoma with normal thyroid-stimulating hormone value: a case report
INTRODUCTION Clear cell carcinomas of the thyroid gland with normal thyroid-stimulating hormone value are very rare, but clear cell changes are described in most reported cases of thyroidal lesions. CASE PRESENTATION In this report, we describe the case of a 50-year-old Caucasian woman with a normal thyroid-stimulating hormone level who underwent surgery to treat a multi-nodular goiter. The p...
متن کاملAnomalous high p27/KIP1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression. p27/KIP1-cyclin D3 colocalization in tumor cells.
p27 cyclin-dependent kinase inhibitor downregulation is essential for transition to the S phase of the cell cycle. Thus, proliferating cells in reactive lymphoid tissue show no detectable p27 expression. Nevertheless, anomalous high p27 expression has been shown to be present in a group of aggressive B-cell lymphomas with high proliferation index and adverse clinical outcome. This suggests that...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 2006
ISSN: 0021-9746
DOI: 10.1136/jcp.2005.036012